Myelin Biogenesis: Sorting out Protein Trafficking
نویسندگان
چکیده
منابع مشابه
Myelin Biogenesis: Sorting out Protein Trafficking
Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport and cytoskeletal dynamics. Recent studies indicate that soluble neuronal signals may control the surface expression of proteolipid protein, a process that involves reduced endocytosis and/or increased transport carrier recruitment from an intracellular pool.
متن کاملSorting out Receptor Trafficking
in membrane or luminal/extracellular domains of these proteins, while somatodendritic signals, like basolateral signals, are found in cytoplasmic domains. However, Establishing and maintaining the proper spatial distribu-there are also contradictions to this " analogous mem-tion of integral membrane proteins is a functional neces-brane domain " hypothesis. Previous structure–function sity of al...
متن کاملSorting signals and regulation of cognate basolateral trafficking in myelin biogenesis.
A detailed understanding of trafficking pathways in mature oligodendrocytes is essential for addressing issues aimed at controlling (re)myelination by modulating myelin-directed transport. Previously, we have shown that viral marker proteins HA and VSV G, on reaching the apical and basolateral surfaces of polarized epithelial cells, respectively, are primarily transported to the plasma membrane...
متن کاملVacuolar biogenesis in yeast: Sorting out the sorting proteins
Roughly 10 years ago, a small number of yeast labs isolated a collection of mutants that missort the enzyme carboxypeptidase Y (CPY) in an attempt to unravel vacuolar protein sorting, a process that is closely related to lysosomal enzyme sorting in mammals. They came up with an overwhelming number of VfS genes-more than 50 so far-and the screen is not saturated (see Stack et al., 1995b). How ca...
متن کاملMembrane Trafficking and Organelle Biogenesis
The PAR polarity complex controls the directional migration of medaka macrophages to sites of tissue injury in vivo A novel regulatory mechanism of AQP2 trafficking to explain the syndrome of inappropriate antidiuresis 15:50-16:10 Alessia Castagnino (Genoa) ErbB2 membrane redistribution induced by Trastuzumab in SKBR3 cells 16:10-16:30 Elisa Duregotti (Padua) Calpains participate in nerve termi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.05.010